Key result
The triglyceride-glucose (TyG) index demonstrated high diagnostic accuracy for screening NAFLD in women with morbid obesity, yielding an AUROC of 0.835 with 95.1% sensitivity and 70.8% specificity.
Why the study?
NAFLD is increasing in Indian women with morbid obesity, but abdominal USG is costly and less accessible, creating a need for affordable screening biomarker panels in resource-limited settings.
Do simple outpatient-based serum biomarker panels accurately detect non-alcoholic fatty liver disease in women with morbid obesity compared to abdominal ultrasound?
Cross-Sectional (n=106)
No
Do simple outpatient-based serum biomarker panels accurately detect non-alcoholic fatty liver disease in women with morbid obesity compared to abdominal ultrasound?
Effect estimate: AUROC 0.835 (95% CI 0.713-0.957)
p-value: p=<0.001
The TyG index is a highly accurate, simple, and affordable outpatient screening tool for detecting non-alcoholic fatty liver disease in women with morbid obesity.
May aid affordable NAFLD screening in morbid obesity; hypothesis-generating, requires prospective validation before any practice change.
ackground.Non-alcoholic fatty liver disease (NAFLD) and related health issues are increasing in Indian women with morbid obesity, but the standard diagnostic tool -abdominal ultrasound sonography (USG) -is costly and less accessible.This study aims to identify an affordable and effective biomarker panel to improve early detection and screening of NAFLD in resource-limited settings.Methods.This cross-sectional study included 106 consecutive patients aged between 18 and 70 years with morbid obesity defined by body mass index (BMI) ≥32.5 kg/m 2 who underwent an abdominal USG for a non-hepatic indication.The serum biomarker indices used were hepatic steatosis index, lipid accumulation product (LAP), Framingham steatosis index, triglyceride-glucose (TyG) index, TyG weight-to-height ratio composite index, TyG-BMI and TyG waist circumference composite index.Results.The mean age was 40.2 ± 10.9 years, and the mean BMI was 41.5 ± 5.8 kg/m 2 .NAFLD was diagnosed in 71.7% of the participants.The TyG index showed the highest diagnostic accuracy with an area under the receiver operating characteristic curve (AUROC) of 0.835 (confidence interval [CI]: 0.713-0.957,p<0.001), with a sensitivity of 95.1% and a specificity of 70.8% at a cut-off of 9.0994.LAP showed an AUROC of 0.711 (CI: 0.584-0.838,p-value: 0.002).Using a cut-off score of 76.2, the sensitivity and specificity were 71.2 and 70.8%, respectively.Conclusion.Simple screening tools can be used to detect fatty liver disease in clinical practice.In our cohort, TyG index was found to be the best tool for identifying NAFLD, with LAP showing potential as a secondary option. Article Highlights •This study aims to find an effective and affordable biomarker panel for early non-alcoholic fatty liver disease (NAFLD) detection
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Saha et al. (2025) conducted a cross-sectional in Steatotic Liver Disease (NAFLD) (n=106). Triglyceride-glucose (TyG) index vs. Abdominal ultrasound sonography (USG) was evaluated on Diagnostic accuracy (AUROC) for NAFLD (AUROC 0.835, 95% CI 0.713-0.957, p=<0.001). The triglyceride-glucose (TyG) index demonstrated high diagnostic accuracy for screening NAFLD in women with morbid obesity, yielding an AUROC of 0.835 with 95.1% sensitivity and 70.8% specificity.
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