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Investigate the infection dynamics, transmission routes, and seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) across diverse camel populations and management settings.

January 1, 2017Emerging Microbes & InfectionsOpen Access

Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt

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Investigate the infection dynamics, transmission routes, and seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) across diverse camel populations and management settings.
Conducted systematic surveillance between June 2014 and February 2016 across quarantines, markets, abattoirs, free-roaming herds, and farmed breeding herds in Egypt.
Collected nasal, rectal, milk, urine, and serum samples from locally raised and imported dromedary camels to evaluate viral RNA via RT-PCR and antibodies via serology.
Overall MERS-CoV seroprevalence was 71% and the viral RNA detection rate was 15%, with imported camels exhibiting higher seroprevalence (90% vs. 61%) and RT-PCR detection (21% vs. 12%) than locally raised camels.
Juveniles had lower seroprevalence than adults (37% vs. 82%) despite similar RT-PCR detection rates (16% vs. 15%), and calves demonstrated very low maternal antibody titers regardless of maternal serostatus.
Longitudinal monitoring of a breeding herd outbreak revealed rapid antibody waning, frequent reinfection, and prolonged viral circulation within the herd.

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Implication

Active surveillance study demonstrates high viral shedding, waning immunity, and reinfection in camels, highlighting trade-driven transmission and challenges for vaccine development.

Cite This Study

Ali et al. (2017) studied this question.

synapsesocial.com/papers/6a941560d5a6dcc35cf64152 https://doi.org/10.1038/emi.2016.130

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Implication

Active surveillance study demonstrates high viral shedding, waning immunity, and reinfection in camels, highlighting trade-driven transmission and challenges for vaccine development.

Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt

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Implication

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Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt

Key Points

Discussion

Implication

Cite This Study

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