Many of the effects of cholinesterase inhibitors resemble those of parasympathomimetic drugs and it is reasonable to suppose that they are due to accumulation of acetylcholine.Stewart (1952) has provided evidence that this occurs.It is therefore to be expected that animals might be partially protected against anticholinesterases if treated with ACh antagonists.Thus, atropine or scopolamine protect against diisopropylphosphorofluoridate (DFP) (Modell and
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Parkes et al. (1954) studied this question.
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