Key result
Transcatheter atrial septal defect closure significantly reduced in-hospital mortality compared to traditional surgery (OR 0.16; 95% CI 0.66-0.44; p=0.0003).
Why the study?
An updated comprehensive comparison between transcatheter device-based and surgical closure in adults regarding in-hospital mortality, perioperative stroke, and atrial fibrillation onset is lacking.
Does transcatheter device-based closure reduce in-hospital mortality and complications compared to surgical closure in adults with secundum atrial septal defects?
Population
2360 adult atrial septal defect patients
Comparison
Transcatheter device-based closure vs surgical closure
Design
Systematic review and meta-analysis
Authors
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Transcatheter ASD closure may reduce in-hospital risks in adults; leaves open need for RCTs to confirm and guide practice.
Meta-Analysis (n=2,360)
Does transcatheter device-based closure reduce in-hospital mortality and complications compared to surgical closure in adults with secundum atrial septal defects?
Odds Ratio: 0.16 (95% CI 0.66–0.44)
p-value: p=0.0003
In adults with secundum atrial septal defects, transcatheter closure is associated with significantly lower in-hospital mortality, perioperative stroke, and post-procedural atrial fibrillation compared to surgical closure.
Rigatelli et al. (2021) conducted a meta-analysis in Atrial septal defect (n=2,360). Transcatheter device-based closure vs. Surgical closure was evaluated on In-hospital mortality from all causes (OR 0.16, 95% CI 0.66-0.44, p=0.0003). Transcatheter atrial septal defect closure significantly reduced in-hospital mortality compared to traditional surgery (OR 0.16; 95% CI 0.66-0.44; p=0.0003).
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