Key result
Screening an unselected population of 1,060 patients with chronic lung disease using dried blood spots detected zero individuals with severe alpha1-Pi deficiency.
Why the study?
Does screening an unselected population of patients with chronic lung disease using dried blood spots increase the detection rate of severe alpha1-Pi deficiency?
Population
1,060 patients with chronic lung disease in the prospective screening cohort, and 555 individuals in the…
Comparison
Screening for alpha1-Pi deficiency using… vs Conventional methods (for the validation cohort)
Design
Cross-sectional
Authors
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Low yield cautions against unselected screening in chronic lung disease; leaves open targeted testing in high-risk subgroups.
Observational (n=1,060)
Does screening an unselected population of patients with chronic lung disease using dried blood spots increase the detection rate of severe alpha1-Pi deficiency?
Screening an unselected population of COPD and asthma patients for alpha1-Pi deficiency using dried blood spots yielded a low detection rate of severe deficiency, similar to the normal population.
Wencker et al. (2002) conducted an observational in Chronic lung disease (COPD and asthma) (n=1,060). Screening for alpha1-Pi deficiency using dried blood spots was evaluated on Detection of severe alpha1-Pi deficiency. Screening an unselected population of 1,060 patients with chronic lung disease using dried blood spots detected zero individuals with severe alpha1-Pi deficiency.
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