Conjugated hyperbilirubinaemia in infancy is always pathological and biliary atresia or choledochal cyst should be suspected if such jaundice persists for more than 2 weeks even if evidence of intrauterine infection, such as cytomegalovirus, has been found. Recent studies have suggested that a laparotomy to confirm or exclude a diagnosis of biliary atresia should be performed in all infants with conjugated hyperbilirubinaemia by 60 days of age providing (1) all known metabolic causes of neonatal hepatitis
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Howard et al. (1977) studied this question.
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