Key result
Alpha-1-antitrypsin deficiency was associated with a concurrent presentation of pulmonary emphysema, hepatic cirrhosis, and intestinal mucosal atrophy.
This case report highlights a potential association between alpha1-antitrypsin deficiency, emphysema, cirrhosis, and intestinal mucosal atrophy.
Intestinal mucosal atrophy may represent an underrecognized manifestation of alpha-1-antitrypsin deficiency; hypothesis-generating and requires confirmation before clinical consideration.
An elderly man with long-standing pulmonary emphysema was seen with recent onset of steatorrhea and ascites. He had very low levels of serum alpha1-antitrypsin, hepatic cirrhosis, and intestinal mucosal atrophy. We believe this this combination of findings did not occur by chance.
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Alan J. Greenwald (1975) studied this question. Alpha-1-antitrypsin deficiency was associated with a concurrent presentation of pulmonary emphysema, hepatic cirrhosis, and intestinal mucosal atrophy.
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