Key result
Low-dose aspirin significantly reduced preeclampsia risk in both East Asian (OR 0.20; 95% CI 0.11-0.35) and non-East Asian (OR 0.84; 95% CI 0.77-0.92) pregnant women at risk for preeclampsia.
Why the study?
Does low-dose aspirin reduce the risk of preeclampsia and fetal complications in East Asian and non-East Asian pregnant women at risk for preeclampsia?
Meta-Analysis
Does low-dose aspirin reduce the risk of preeclampsia and fetal complications in East Asian and non-East Asian pregnant women at risk for preeclampsia?
Low-dose aspirin reduces the risk of preeclampsia in both East Asian and non-East Asian pregnant women, with a significant reduction in IUGR observed only in East Asians.
Answers are grounded in this paper and cite their sources.
Supports low-dose aspirin for preeclampsia prevention across ethnicities; extends evidence by revealing ethnicity-specific IUGR benefits.
BACKGROUND: Low-dose aspirin can reduce the incidence of preeclampsia and intrauterine growth restriction (IUGR). However, the effects of ethnicity upon low-dose aspirin's efficacy has not been analyzed. Here, we comparatively evaluated the efficacy of low-dose aspirin in preventing preeclampsia and related fetal complications in East Asian and non-East Asian pregnant women at risk for preeclampsia. METHODS: Several databases were searched for randomized controlled trials (RCTs) comparing low-dose aspirin with either placebo or no treatment in pregnant women at risk for preeclampsia. Odds ratios (ORs) and associated 95% confidence intervals (CIs) for preeclampsia and related fetal outcomes were tabulated. RESULTS: Low-dose aspirin significantly reduced preeclampsia risk in both East Asians (OR = 0.20, 95% CI: 0.11-0.35) and non-East Asians (OR = 0.84, 95% CI: 0.77-0.92). Low-dose aspirin significantly reduced IUGR risk in East Asians (OR = 0.36, 95% CI: 0.20-0.67) but not in non-East Asians (OR = 0.85, 95% CI: 0.41-1.77). Low-dose aspirin did not significantly reduce the risk of cesarean section in either East Asians (OR = 0.67, 95% CI: 0.14-3.22) or non-East Asians (OR = 1.01, 95% CI: 0.86-1.19). CONCLUSIONS: Low-dose aspirin is effective in reducing preeclampsia risk in both East Asians and non-East Asians and has differential effects in East Asians and non-East Asians with respect to IUGR.
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Gan et al. (2016) conducted a meta-analysis in Pregnant women at risk for preeclampsia. Low-dose aspirin vs. Placebo or no treatment was evaluated on Preeclampsia (OR 0.20 (East Asians) and OR 0.84 (non-East Asians), 95% CI 0.11-0.35 (East Asians) and 0.77-0.92 (non-East Asians)). Low-dose aspirin significantly reduced preeclampsia risk in both East Asian (OR 0.20; 95% CI 0.11-0.35) and non-East Asian (OR 0.84; 95% CI 0.77-0.92) pregnant women at risk for preeclampsia.
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