Key result
Mononuclear cells from patients with clinically active sarcoidosis spontaneously produced CDI-MLx in amounts comparable to maximally stimulated normal cells.
Population
Patients with clinically active and inactive sarcoidosis, and normal controls
Design
Other
Authors
Loading...
May not alter sarcoidosis management; leaves open whether CDI-MLx inhibition could modulate granuloma formation in vivo.
Observational
In active sarcoidosis, a subpopulation of natural killer-like cells spontaneously produces a monocyte leukotaxis inhibitor, which may play a role in granuloma formation.
Campbell et al. (1986) conducted an observational in Sarcoidosis. Clinically active sarcoidosis vs. Inactive disease and normal cells was evaluated on Production of cell-directed inhibitor of monocyte leukotaxis (CDI-MLx). Mononuclear cells from patients with clinically active sarcoidosis spontaneously produced CDI-MLx in amounts comparable to maximally stimulated normal cells.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: