The effect of breathing 100 % oxygen at 1 and 3 atmospheres absolute was studied in relation to the accumulation of 3H-lysine into different brain regions, plasma, muscle and liver of ethanol-anesthetized and unanesthetized rats, as well as into the TCA-precipitable protein (PCF) of brain, plasma, muscle and liver. It was shown that hyperoxia at 1 and 3 ATA caused a depression of the 3H-lysine accumulation into the hypothalamus and cerebellum of unanesthetized rats two hours after the injection of the amino acid. Hyperoxia at 3 ATA also caused a depression of lysine accumulation into white matter 2 hours after injection. No changes were noted in the ethanol-anesthetized rats. By group analysis, there was also a depression of 3H-lysine accumulation in the cerebral grey matter in the 1 ATA animals at both levels of anesthesia. Hyperoxia at 1 and 3 ATA caused a depression in the 3H-lysine accumulation into plasma protein at two and three hours in unanesthetized rats and had somewhat more variable effects in the anesthetized animals. In the skeletal muscle, hyperoxia caused an increase in amino acid accumulation in animals breathing 100 % 02 at 3 ATA as compared to those breathing air or 100 % oxygen at 1 ATA when compared by group analysis of whole tissue. Analysis of the muscle PCF revealed a depression in lysine uptake associated with anesthesia (group analysis), and changes in all groups related to time elapsed since injection of labelled amino acid. Finally, 02 at 1 ATA was observed to depress amino acid accumulation while 02 at 3 ATA had no effect in the unanesthetized rats. In the liver, there was a significant depression of 3H-lysine accumulation in those animals breathing 100 % oxygen at 1 ATA as compared to controls in both the ethanol-anesthetized and unanesthetized rats. 3H-lysine accumulation
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Choy et al. (1972) studied this question.
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