Key result
Chronic nitroglycerine administration reduces vascular reactivity and downregulates the endothelium-derived hyperpolarizing factor (EDHF) mechanism.
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May warrant caution with chronic nitroglycerin use; leaves open EDHF's role in tolerance for prospective study.
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Weid et al. (2005) studied this question. Chronic nitroglycerine administration reduces vascular reactivity and downregulates the endothelium-derived hyperpolarizing factor (EDHF) mechanism.
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