Key result
Nitroglycerin did not alter the maximum contractile element velocity in isolated cat papillary muscles, indicating it does not decrease myocardial oxygen consumption by diminishing contractility.
Population
four isolated cat papillary muscles
Design
Preclinical
Authors
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NTG lacks direct negative inotropy in isolated muscle; leaves open alternative mechanisms for reduced myocardial O2 demand in vivo.
Nitroglycerin does not appear to decrease myocardial oxygen consumption by directly diminishing myocardial contractility.
R. ZELLIS (1970) studied Angina Pectoris (n=4). Nitroglycerin was evaluated on maximum contractile element velocity. Nitroglycerin did not alter the maximum contractile element velocity in isolated cat papillary muscles, indicating it does not decrease myocardial oxygen consumption by diminishing contractility.
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