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August 30, 2026Expert Review of Medical Devices

Transcatheter tricuspid valve replacement for severe tricuspid regurgitation: current and future perspectives

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Why the study?

Severe tricuspid regurgitation is common, undertreated, and associated with significant morbidity and mortality, with TTVR emerging as a promising option for patients unsuitable for surgery or TEER.

Design

Systematic review

Key result

Transcatheter tricuspid valve replacement offers near-complete regurgitation elimination for severe tricuspid regurgitation, particularly in patients with anatomy unfavorable for repair.

Authors

GCGianmaria CalamitaPLPier Pasquale LeoneOEOssama Elsaid

Discussion

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Overview

TTVR offers a potential option for severe TR ineligible for surgery or TEER; leaves open need for randomized data on durability and outcomes.

Key Points

  • To review the evolution, current device landscape, procedural challenges, and future clinical directions of transcatheter tricuspid valve replacement for severe tricuspid regurgitation.
  • Conducted a systematic review of literature published between January 2015 and May 2025 using PubMed/MEDLINE, Embase, and ClinicalTrials.gov.
  • Synthesized evidence regarding device innovation, patient selection, intraprocedural imaging guidance, and procedural challenges.
  • Transcatheter tricuspid valve replacement provides near-complete elimination of regurgitation, especially in patients with anatomy unfavorable for surgical or edge-to-edge repair.
  • Treatment efficacy depends strongly on patient-specific cardiac anatomy and the underlying mechanism of regurgitation.
  • Prospective randomized trials are needed to clarify procedural timing, optimal device selection, antithrombotic therapy, and long-term valve durability.

Structured PICO

P
Population
Patients with severe tricuspid regurgitation unsuitable for surgical repair or transcatheter edge-to-edge repair
I
Intervention
Transcatheter tricuspid valve replacement (TTVR)

TTVR is a promising option for severe tricuspid regurgitation in patients unsuitable for surgical or transcatheter edge-to-edge repair, offering near-complete regurgitation elimination.

Limitations

  • Optimal timing, device selection, antithrombotic management, and long-term durability require prospective validation through dedicated trials and head-to-head comparisons with repair strategies.

Cite This Study

Calamita et al. (2026) conducted a review in Severe tricuspid regurgitation. Transcatheter tricuspid valve replacement (TTVR) was evaluated. Transcatheter tricuspid valve replacement offers near-complete regurgitation elimination for severe tricuspid regurgitation, particularly in patients with anatomy unfavorable for repair.

synapsesocial.com/papers/6a941e796c1a8fb52e79e879https://doi.org/10.1080/17434440.2026.2713742
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcatheter Tricuspid Valve Replacement: A Feasible Solution to a Real-world Problem2022 · 3 citations
  2. 2Transcatheter Tricuspid Valve Replacement2024 · 87 citations
  3. 3A comprehensive overview of surgical and transcatheter therapies to treat tricuspid regurgitation in patients with heart failure2023 · 3 citations
  4. 4Transcatheter Tricuspid Valve Intervention: Current Perspective2021 · 6 citations
  5. 5Transcatheter Therapy for the Tricuspid Valve: A Focused Review of Edge-to-Edge Repair and Orthotopic Valve Replacement2024 · 16 citations