Key result
Transcatheter tricuspid valve interventions, including edge-to-edge repair and orthotopic replacement, safely reduce severe tricuspid regurgitation and improve health status, though their impact on hard clinical endpoints remains uncertain.
Why the study?
Severe tricuspid regurgitation carries significant morbidity and mortality, making less invasive transcatheter alternatives to surgery an important treatment option.
Does transcatheter tricuspid valve intervention improve outcomes in patients with severe tricuspid regurgitation?
Does transcatheter tricuspid valve intervention improve outcomes in patients with severe tricuspid regurgitation?
Answers are grounded in this paper and cite their sources.
Transcatheter tricuspid valve interventions, including T-TEER and TTVR, offer safe and effective less-invasive alternatives for reducing severe tricuspid regurgitation and improving patient quality of life.
PURPOSE OF REVIEW: Patients with severe tricuspid regurgitation (TR) are at risk for significant morbidity and mortality. Transcatheter tricuspid valve interventions (TTVI) may offer patients less invasive treatment alternatives to surgery. This review evaluates the most common class of device currently used worldwide to treat TR, tricuspid transcatheter edge-to-edge repair (T-TEER) and orthotopic transcatheter tricuspid valve replacement (TTVR), both of which are now approved in the USA and Europe. RECENT FINDINGS: The first pivotal randomized clinical trial, TRILUMINATE, demonstrated that T-TEER can safely reduce TR and is associated with improved health status outcomes. However, results of this trial have raised questions about whether this device can provide sufficient TR reduction to impact clinical outcomes. Orthotopic TTVR has recently gained attention with initial data suggesting near-complete TR elimination. The current review examines the technical features and anatomic limitations of the most commonly used devices for T-TEER and orthotopic TTVR, discusses the current clinical data for these devices, and offers a theoretical construct for device selection.
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Madhavan et al. (2024) conducted a review in Severe tricuspid regurgitation. Transcatheter tricuspid valve interventions (T-TEER and TTVR) was evaluated. Transcatheter tricuspid valve interventions, including edge-to-edge repair and orthotopic replacement, safely reduce severe tricuspid regurgitation and improve health status, though their impact on hard clinical endpoints remains uncertain.
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