Transcatheter Therapy for the Tricuspid Valve: A Focused Review of Edge-to-Edge Repair and Orthotopic Valve Replacement
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Why the study?
Severe tricuspid regurgitation carries significant morbidity and mortality, making less invasive transcatheter alternatives to surgery an important treatment option.
Does transcatheter tricuspid valve intervention improve outcomes in patients with severe tricuspid regurgitation?
Comparison
T-TEER vs orthotopic TTVR
Design
Focused review
Key result
Transcatheter tricuspid valve interventions, including edge-to-edge repair and orthotopic replacement, safely reduce severe tricuspid regurgitation and improve health status, though their impact on hard clinical endpoints remains uncertain.
Authors
Discussion
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Overview
T-TEER and TTVR now approved for severe TR; extends less-invasive options while leaving long-term outcomes open.
Structured PICO
Does transcatheter tricuspid valve intervention improve outcomes in patients with severe tricuspid regurgitation?
P
Population
A focused review evaluating the technical features, anatomic limitations, and clinical outcomes of transcatheter edge-to-edge repair and orthotopic valve replacement for patients with severe tricuspid regurgitation.
I
Intervention
Transcatheter tricuspid valve interventions (TTVI), specifically tricuspid transcatheter edge-to-edge repair (T-TEER) and orthotopic transcatheter tricuspid valve replacement (TTVR)
Transcatheter tricuspid valve interventions, including T-TEER and TTVR, offer safe and effective less-invasive alternatives for reducing severe tricuspid regurgitation and improving patient quality of life.
Limitations
- Lack of long-term data on mortality and heart failure hospitalizations
- Open-label trial designs and lack of sham controls in some pivotal studies
Cite This Study
Madhavan et al. (2024) conducted a review in Severe tricuspid regurgitation. Transcatheter tricuspid valve interventions (T-TEER and TTVR) was evaluated. Transcatheter tricuspid valve interventions, including edge-to-edge repair and orthotopic replacement, safely reduce severe tricuspid regurgitation and improve health status, though their impact on hard clinical endpoints remains uncertain.
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