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Twenty-four days after hy-pophysectomy both hypothalamic somatostatin and LH-RH contents decreased to 1/3 of the control values in male rats. The LH-RH remained unchanged thereafter, whereas the somatostatin continued to fall until 2.5 months after hypophysectomy. The hypothalamic somatostatin and LH-RH contents in 117 day old rats (24.5 and 6.0 ng, respectively) were significantly lower than those in 59-day-old rats (49 and 9.1 ng, respectively).
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Fernández‐Durango et al. (1978) studied this question.
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