January 1, 2008Journal of Pediatric Endocrinology and Metabolism

Insulin-like Growth Factor-I (rhIGF-I) Therapy of Short Stature

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Why the study?

Does rhIGF-I therapy improve growth in children with short stature?

Population

Children with severe short stature from growth hormone insensitivity due to genetic defects in the GH…

Design

Review

Authors

ARArlan L. RosenbloomFlorida College

Discussion

Member takes

Implication

Supports restricting rhIGF-I to FDA-approved GH insensitivity; leaves open efficacy in other short stature causes.

Structured PICO

Does rhIGF-I therapy improve growth in children with short stature?

Population

Children with severe short stature from growth hormone (GH) insensitivity due to genetic defects in the GH receptor or postreceptor mechanisms or from the development of GH inactivating antibodies, and children with idiopathic short stature (ISS)

Intervention

Subcutaneously injected rhIGF-I

Outcome

Growth improvement

The use of rhIGF-I should be restricted to FDA-approved conditions of severe GH insensitivity, as off-label use lacks efficacy data and carries significant risks.

Cite This Study

Arlan L. Rosenbloom (2008) studied this question.

synapsesocial.com/papers/6a9422313fda5c29338c12dc https://doi.org/10.1515/jpem.2008.21.4.301

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Insulin-like Growth Factor-I (rhIGF-I) Therapy of Short Stature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insulin-like Growth Factor-I (rhIGF-I) Therapy of Short Stature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider