Use of high lateral resolution secondary-ion mass spectrometry to characterize self-assembled monolayers on microfabricated structures

Our work on the surface coordination chemistry of microfabricated structures has inspired us to develop methodologies for detecting the presence of a monolayer of surface-confined molecules at high lateral resolution. Previous work from this laboratory has shown that it is possible to selectively derivatize microlithographically patterned Gort and Platinum surfaces with self- assembled monolayers (SAMs) of redox active molecules, R-L, as shown in Scheme I, where L is -SH or -NC, known to coordinate to Au and Pt. Verification of the selective binding of intact molecules in our studies to date has been provided by a combination of electrochemical and surface sensitive spectroscopic techniques, including cyclic voltammetry, X-ray photoelectron spectroscopy (XPS) and scanning Auger electron spectroscopy (AES).