Why the study?
The study tested the hypothesis that vitronectin is regulated as an acute phase reactant in response to inflammatory stimuli.
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Vitronectin acts as an acute phase reactant that is up-regulated during acute and chronic inflammation, a process primarily mediated by IL-6.
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Lowres et al. (2020) studied Acute and chronic inflammation. Inflammatory stimuli (surgery, LPS, CFA, turpentine, IL-6) was evaluated on Vitronectin (Vn) levels and hepatic Vn mRNA expression.
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