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In Brief A 62-year-old woman received injections of Restylane, cross-linked hyaluronic acid, for the cosmetic filling of facial rhytids and developed a severe dermal inflammatory reaction. Hyaluronidase administered directly in the inflammatory nodules resulted in rapid resolution of pain, palpable nodularity, and visible induration possibly due to dissolution of the hyaluronic acid. Locally injected hyaluronidase is an effective alternative for the management of Restylane-induced dermal inflammation.
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Soparkar et al. (2005) studied this question.
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