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October 10, 2011Journal of Pharmacy Practice

Comparative Effectiveness of Dalteparin and Enoxaparin in a Hospital Setting

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Key result

Dalteparin was similarly effective as enoxaparin for VTE prophylaxis, with no significant differences in VTE or bleeding rates, while achieving $40,788 in savings over 6 months.

Why the study?

Does dalteparin compared to enoxaparin prevent VTE in hospitalized patients at risk?

Population

Hospitalized patients at risk of venous thromboembolism

Comparison

Dalteparin for VTE prophylaxis vs Enoxaparin for VTE prophylaxis

Design

Cohort

Follow-up

In-hospital

Authors

WCWilliam R. CarsonUniversidade do PortoBSBlane SchillingAspen UniversityWSW. Robert SimonsMiles College

Discussion

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Implication

May support dalteparin interchange for VTE prophylaxis with cost savings; hypothesis-generating pending randomized confirmation.

Study Design

Type

Cohort (n=3,509)

Structured PICO

Does dalteparin compared to enoxaparin prevent VTE in hospitalized patients at risk?

P
Population
3,509 hospitalized patients at risk of venous thromboembolism who received either enoxaparin or dalteparin prophylaxis.
E
Exposure
Dalteparin for VTE prophylaxis
C
Comparator
Enoxaparin for VTE prophylaxis
O
Outcome
Venous thromboembolism (VTE) rateshard clinical

A therapeutic interchange from enoxaparin to dalteparin for VTE prophylaxis in hospitalized patients maintains clinical efficacy and safety while providing cost savings.

Cite This Study

Carson et al. (2011) conducted a cohort in Venous thromboembolism (VTE) risk (n=3,509). Dalteparin vs. Enoxaparin was evaluated on VTE rates. Dalteparin was similarly effective as enoxaparin for VTE prophylaxis, with no significant differences in VTE or bleeding rates, while achieving $40,788 in savings over 6 months.

synapsesocial.com/papers/6a9424131e998d99dafeebc3https://doi.org/10.1177/0897190011418514
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