Key result
Nephropathy in type 1 diabetes patients significantly impairs muscle energy metabolism, evidenced by reduced relative β-ATP, increased Pi, and prolonged phosphocreatine recovery time after exercise.
Why the study?
Does nephropathy alter skeletal muscle energy metabolism measured by 31P MR spectroscopy in patients with Type 1 diabetes?
Cross-Sectional (n=77)
No
Does nephropathy alter skeletal muscle energy metabolism measured by 31P MR spectroscopy in patients with Type 1 diabetes?
Nephropathy in Type 1 diabetes is associated with impaired skeletal muscle energy metabolism, reflected by reduced ATP at rest and prolonged phosphocreatine recovery after exercise.
Answers are grounded in this paper and cite their sources.
Should not yet change practice in type 1 diabetes; leaves open whether muscle metabolic impairment affects clinical outcomes.
Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and 13 m/5 f with nephropathy) and 26 (14 m/12 f) healthy volunteers were examined using (31)P magnetic resonance spectroscopy at 3T tomograph at rest, and during and after a calf muscle exercise. The exercise consisted of a six-minute plantar flexion using a pedal ergometer followed by a six-minute recovery. It is reflected by reduced relative beta-ATP and increased Pi and phosphodiester signals to phosphocreatine (PCr) at rest and prolongation of the PCr recovery time after the exercise. Measurement on healthy volunteers indicated differences between males and females in pH at the rest and after the exercise only. These differences between patients groups were not significant. We have proven that nephropathy affects the metabolism in diabetic patients and our results confirm significant difference between patients with and without nephropathy. Gender differences in pH were observed only between male and female healthy volunteers.
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Šedivý et al. (2018) conducted a cross-sectional in Type I Diabetes Mellitus (n=77). Type 1 diabetes with nephropathy vs. Healthy controls and type 1 diabetes without nephropathy was evaluated on Muscle metabolism parameters (β-ATP/Ptot, Pi/Ptot, PDE/Ptot, and PCr recovery time) (p=<0.05). Nephropathy in type 1 diabetes patients significantly impairs muscle energy metabolism, evidenced by reduced relative β-ATP, increased Pi, and prolonged phosphocreatine recovery time after exercise.
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