Key result
Type I diabetes mellitus in young subjects was associated with significantly higher resting forearm blood flow compared to controls (3.3 vs 2.2 ml/min/100 ml; P<0.005).
Why the study?
Is resting and exercise-induced skeletal muscle blood flow augmented in young patients with type I diabetes mellitus compared to matched controls?
Population
18 young subjects with type I (insulin-dependent) diabetes mellitus and 20 matched controls
Comparison
Assessment of forearm blood flow by venous… vs 20 matched controls
Design
Case-control
Authors
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Should not change practice in young T1DM; hypothesis-generating for insulin-mediated skeletal muscle hyperperfusion.
Case-Control (n=38)
Is resting and exercise-induced skeletal muscle blood flow augmented in young patients with type I diabetes mellitus compared to matched controls?
Absolute Event Rate: 3.3% vs 2.2%
p-value: p=<0.005
Resting and exercise-induced skeletal muscle blood flow are augmented in young patients with type I diabetes, possibly due to the vasodilatory effect of increased insulin levels.
SKYRME-JONES et al. (1999) conducted a case-control in Type I diabetes mellitus (n=38). Type I diabetes mellitus vs. Matched controls was evaluated on Resting forearm blood flow (ml/min/100 ml) (p=<0.005). Type I diabetes mellitus in young subjects was associated with significantly higher resting forearm blood flow compared to controls (3.3 vs 2.2 ml/min/100 ml; P<0.005).
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