Key result
Type 1 diabetes linked to ~50% lower peripheral skeletal muscle perfusion versus healthy controls.
Cross-Sectional (n=37)
No
Absolute Event Rate: 0.22% vs 0.44%
p-value: p=<0.05
Type 1 diabetes is associated with congruent impairment of both microvascular skeletal muscle perfusion and macrovascular flow-mediated dilation, even in the absence of other cardiovascular risk factors.
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Indicates early microvascular impairment in T1DM without other risks; hypothesis-generating and requires prospective studies before clinical adoption.
Irace et al. (2017) conducted a cross-sectional in Type 1 diabetes mellitus (n=37). Type 1 diabetes mellitus vs. Healthy controls was evaluated on Baseline skeletal muscle perfusion (Video Intensity in a.u./mm2) (p=<0.05). Type 1 diabetes mellitus was associated with significantly lower peripheral skeletal muscle perfusion at baseline (0.22 vs 0.44 a.u./mm2) and after ischemia compared to healthy controls.
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