Key result
Higher histological grade (HR 2.42, P<0.001) and tumor invasion of adjacent structures (HR 1.37, P<0.001) predicted worse survival after retroperitoneal sarcoma resection, but tumor size did not.
Authors
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May enhance postoperative risk stratification; extends Level 3 evidence but requires prospective validation before practice change.
Cohort (n=1,365)
Yes
Hazard Ratio: 2.42
p-value: p=<0.001
Nathan et al. (2009) conducted a cohort in Primary retroperitoneal sarcoma (n=1,365). Histological grade 3-4 vs. Histological grade 1 was evaluated on Survival after resection (HR 2.42, p=<0.001). Higher histological grade (HR 2.42, P<0.001) and tumor invasion of adjacent structures (HR 1.37, P<0.001) predicted worse survival after retroperitoneal sarcoma resection, but tumor size did not.
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