Key result
Melatonin blunted the blood pressure response to first morning orthostatism and significantly increased the norepinephrine dose required to raise systolic blood pressure by 30 mm Hg.
Why the study?
Does melatonin 10 mg reduce morning blood pressure surge and norepinephrine-induced vasoconstriction in healthy male volunteers?
RCT (n=12)
Double-blind
Crossover
No
Does melatonin 10 mg reduce morning blood pressure surge and norepinephrine-induced vasoconstriction in healthy male volunteers?
Absolute Event Rate: 123.06% vs 91.8%
p-value: p=<0.05
A single 10 mg dose of melatonin blunts the morning orthostatic blood pressure surge and reduces the pressor effect of norepinephrine in healthy young men, suggesting potential central and peripheral hypotensive properties.
Supports exploration in morning hypertension; extends RCT evidence for melatonin's hemodynamic effects.
Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics.
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Carranza-Madrigal et al. (2015) conducted an RCT in Healthy volunteers (n=12). Melatonin vs. Placebo was evaluated on Norepinephrine dose required to reach a 30 mm Hg increase in systolic blood pressure (p=<0.05). Melatonin blunted the blood pressure response to first morning orthostatism and significantly increased the norepinephrine dose required to raise systolic blood pressure by 30 mm Hg.
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