Key result
Maximum home systolic blood pressure demonstrated a significantly stronger association with maximum carotid intima-media thickness compared to mean systolic blood pressure (p<0.001).
Why the study?
Maximum home systolic blood pressure has been reported as a parameter of blood pressure variability, but whether it is a risk factor for hypertensive target organ damage remained to be tested.
Is maximum home systolic blood pressure a stronger marker of hypertensive target organ damage than mean home systolic blood pressure in subjects with cardiovascular risk factors?
Cross-Sectional (n=4,310)
Is maximum home systolic blood pressure a stronger marker of hypertensive target organ damage than mean home systolic blood pressure in subjects with cardiovascular risk factors?
Maximum home systolic blood pressure is a stronger marker for carotid atherosclerosis than mean home systolic blood pressure, suggesting its utility in clinical assessment.
Hypothesis-generating for maximum home SBP in carotid atherosclerosis assessment; prospective validation needed before clinical adoption.
Background: Maximum home systolic blood pressure (maximum SBP) has been reported as a parameter of blood pressure (BP) variability. We tested the hypothesis that maximum SBP is one of the risk factors of hypertensive target organ damage (TOD).Methods: We conducted a cross-sectional study of 4,310 subjects with>1 cardiovascular risk factor. The subjects measured their home BP for 14 consecutive days. Mean and maximum SBPs were used as independent variables. As dependent variables, we used left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thickness (CIMT), and urine albumin creatinine ratio (UACR).Results: In a multiple regression analysis, the subjects' mean and maximum SBPs were significantly associated with the above TOD markers. Compared to mean SBP, maximum SBP demonstrated a significantly stronger association with CIMT (p<0.001).Conclusion: Based on its clinical significance herein, measurement of maximum home SBP is warranted in addition to measurement of mean home SBP.
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Kaihara et al. (2019) conducted a cross-sectional in Cardiovascular risk (n=4,310). Maximum home systolic blood pressure vs. Mean home systolic blood pressure was evaluated on Target organ damage markers including LVMI, baPWV, maximum CIMT, and UACR (p=<0.001). Maximum home systolic blood pressure demonstrated a significantly stronger association with maximum carotid intima-media thickness compared to mean systolic blood pressure (p<0.001).
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