Key result
High dietary sodium intake for 6 weeks increased renal cortical vascular sensitivity to adrenergic agonists in Wistar-Kyoto rats (P < 0.05) and functionally involved alpha(1B)-adrenoceptors.
Population
Wistar-Kyoto rats
Comparison
High sodium diet (saline to drink for 6 weeks) vs Normal sodium diet
Design
Preclinical
Follow-up
6 weeks
Authors
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Hypothesis-generating for salt effects on renal vessels in rats; leaves open human translational relevance.
p-value: p=< 0.05
High dietary sodium intake in Wistar-Kyoto rats increases renal cortical vascular sensitivity to adrenergic agonists and induces functional involvement of alpha1B-adrenoceptors.
Kazi et al. (2009) studied this question. High dietary sodium intake (saline to drink) vs. Normal sodium diet was evaluated on Renal cortical vascular responses to adrenergic agonists (noradrenaline, methoxamine, and phenylephrine) (p=< 0.05). High dietary sodium intake for 6 weeks increased renal cortical vascular sensitivity to adrenergic agonists in Wistar-Kyoto rats (P < 0.05) and functionally involved alpha(1B)-adrenoceptors.
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