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September 1, 1994Journal of Virology

Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs

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Population

Transfected cells expressing HIV-1 RNAs

Comparison

Presence of functional HIV-1 Rev protein vs Absence of functional HIV-1 Rev protein

Design

Preclinical

Authors

LCLia H. CampbellApplied Tissue Technologies (United States)KBKeith BorgCharleston Area Medical CenterJHJulia K. HainesMedical University of South Carolina

Discussion

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Implication

No immediate clinical implications; leaves open whether disrupting Rev-PAB1 association could yield new antiviral strategies.

Structured PICO

P
Population
Transfected cells expressing HIV-1 RNAs
I
Intervention
Presence of functional HIV-1 Rev protein
C
Comparator
Absence of functional HIV-1 Rev protein
O
Outcome
Association of poly(A)-binding protein 1 (PAB1) with cytoplasmic HIV-1 RNAssurrogate

HIV-1 Rev is required for the association of poly(A)-binding protein 1 (PAB1) with Rev-dependent RNAs in the cytoplasm, which is critical for their stability and translation.

Cite This Study

Campbell et al. (1994) studied this question.

synapsesocial.com/papers/6a942e24a09a696dc39c4ef6https://doi.org/10.1128/jvi.68.9.5433-5438.1994
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of human immunodeficiency virus env expression by the rev gene product1989 · 367 citations
  2. 2The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro.1989 · 378 citations
  3. 3Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.1993 · 284 citations
  4. 4The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.1978 · 441 citations
  5. 5A Protein of Molecular Weight 78,000 Bound to the Polyadenylate Region of Eukaryotic Messenger RNAs1973 · 352 citations