Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 9, 2024Cardiovascular DiabetologyOpen Access

Melatonin significantly alleviated cardiac dysfunction and improved autophagy of cardiomyocytes in type 1 diabetes mellitus-induced cardiomyopathy mice via the VEGF-B/GRP78/PERK signaling pathway.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Melatonin attenuates diabetic cardiomyopathy, but the underlying mechanism and the role of VEGF-B remain unclear.

Does melatonin improve cardiac dysfunction in type 1 diabetes mellitus induced cardiomyopathy mice?

Population

T1DM-induced cardiomyopathy mice and high glucose-treated neonatal rat ventricular myocytes

Comparison

Melatonin vs controls with VEGF-B, PERK, or autophagy modulation

Design

Preclinical animal and cellular experimental study

Key result

Melatonin significantly alleviated cardiac dysfunction and improved autophagy of cardiomyocytes in type 1 diabetes mellitus-induced cardiomyopathy mice via the VEGF-B/GRP78/PERK signaling pathway.

Authors

SZShengzheng ZhangWTWencong TianXDXianxian Duan

Discussion

Loading...

Member takes

Overview

Does not support clinical use in diabetic cardiomyopathy; leaves open human translation of this pathway.

Structured PICO

Does melatonin improve cardiac dysfunction in type 1 diabetes mellitus induced cardiomyopathy mice?

P
Population
42 eight-week-old male C57BL/6 mice with streptozotocin-induced type 1 diabetes mellitus, treated with melatonin for 7 weeks.
I
Intervention
Melatonin (20 mg/kg orally daily for 7 weeks in mice; 100 µM for 4 hours in NRVMs).
C
Comparator
Saline (0.1 ml per 10 g body weight) in diabetic mice; untreated high glucose in NRVMs.
O
Outcome
Cardiac dysfunction (ejection fraction and fractional shortening) and cardiomyocyte autophagy.surrogate

Main Result

p-value: p=<0.05

Melatonin attenuates diabetic cardiomyopathy by increasing cardiomyocyte autophagy via the VEGF-B/GRP78/PERK signaling pathway, suggesting a potential therapeutic target for diabetic cardiomyopathy.

Cite This Study

Zhang et al. (2024) studied Diabetic cardiomyopathy (n=42). Melatonin vs. Saline was evaluated on Cardiac function (ejection fraction and fractional shortening) and cardiomyocyte autophagy (p=<0.05). Melatonin significantly alleviated cardiac dysfunction and improved autophagy of cardiomyocytes in type 1 diabetes mellitus-induced cardiomyopathy mice via the VEGF-B/GRP78/PERK signaling pathway.

synapsesocial.com/papers/6a9430ea189c14fbc5b95473https://doi.org/10.1186/s12933-023-02078-x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preventive Antiarrhythmic Properties of Melatonin in Experimental Diabetic Cardiomyopathy in Rats2026
  2. 2Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus2020 · 32 citations
  3. 3Melatonin Attenuates Glucolipotoxicity-Induced Cardiac Oxidative Stress, Inflammation, Pyroptosis, and Fibrotic Remodeling in STZ/HFD-Treated ApoE−/− Mice2026
  4. 4Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR‐141‐mediated NLRP3 inflammasome and TGF‐β1/Smads signaling in diabetic cardiomyopathy2020 · 170 citations
  5. 5Melatonin Attenuates Cardiac Dysfunction and Inflammation in Dilated Cardiomyopathy via M2 Macrophage Polarization2024 · 2 citations