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June 6, 2026Journal of Pineal Research

Melatonin mitigates myocardial fibrosis and prevents reperfusion VT/VF in diabetic rats.

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Why the study?

Diabetes mellitus promotes cardiac arrhythmias while melatonin has antiarrhythmic effects, and their overlapping cellular targets warranted testing melatonin as an antiarrhythmic agent in DM.

Does melatonin prevent arrhythmias and electrophysiological changes in an experimental diabetic cardiomyopathy rat model?

Population

41 control and 71 diabetic rats

Comparison

Oral melatonin (10 mg/kg daily) vs placebo

Design

Animal experimental study

Follow-up

1 month

Key result

Melatonin treatment in diabetic rats mitigated myocardial fibrosis and prevented diabetes-related electrophysiological changes and reperfusion ventricular tachycardia/fibrillation.

Authors

AOAlexey O. OvechkinMGMikhail A. GonotkovAAAlena S. Abramochkina

Discussion

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Overview

May support melatonin for arrhythmia prevention in diabetic cardiomyopathy models; leaves open human translation.

Key Points

  • The study aims to evaluate the antiarrhythmic properties of melatonin in an experimental model of diabetic cardiomyopathy.
  • Conducted experiments on 41 control and 71 diabetic rats, with 34 treated with melatonin for 1 month.
  • Utilized electrocardiography, epicardial mapping, patch-clamp studies, and histological techniques including RT-PCR and Western blotting.
  • Assessed the effects of melatonin on conduction velocity, repolarization parameters, and myocardial fibrosis.
  • Melatonin treatment prevented the decrease in conduction velocity and increased dispersion of repolarization (QRS, QT intervals).
  • Significantly reduced calcium current and prevented action potential duration prolongation in patch-clamp studies.
  • Prevented the upregulation of Gja1 gene expression and increase in Cx43 protein level in diabetic rats.

Structured PICO

Does melatonin prevent arrhythmias and electrophysiological changes in an experimental diabetic cardiomyopathy rat model?

P
Population
112 rats (41 control, 71 diabetic) evaluated for electrophysiological and antiarrhythmic properties of melatonin over 1 month.
I
Intervention
Melatonin 10 mg/kg orally daily for 1 month
C
Comparator
Placebo
O
Outcome
Electrophysiological and antiarrhythmic properties (conduction velocity, repolarization duration/dispersion, ECG parameters, reperfusion ventricular tachycardia/fibrillation)surrogate

Melatonin confers antiarrhythmic effects and mitigates electrophysiological changes and myocardial fibrosis in a rat model of diabetic cardiomyopathy.

Cite This Study

Ovechkin et al. (2026) studied Experimental diabetic cardiomyopathy (n=112). Melatonin vs. Placebo was evaluated on Electrophysiological and antiarrhythmic properties (including conduction velocity, repolarization, and reperfusion ventricular tachycardia/fibrillation). Melatonin treatment in diabetic rats mitigated myocardial fibrosis and prevented diabetes-related electrophysiological changes and reperfusion ventricular tachycardia/fibrillation.

synapsesocial.com/papers/6a23bbbb71a5da9775e7732fhttps://doi.org/10.1111/jpi.70153
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1C75-16 Melatonin and Cardiometabolic Outcomes in Diabetes: A Systematic Review of Experimental and Clinical Evidence2026
  2. 2Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway2024 · 32 citations
  3. 3Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR‐141‐mediated NLRP3 inflammasome and TGF‐β1/Smads signaling in diabetic cardiomyopathy2020 · 170 citations
  4. 4Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus2020 · 32 citations
  5. 5Melatonin Attenuates Glucolipotoxicity-Induced Cardiac Oxidative Stress, Inflammation, Pyroptosis, and Fibrotic Remodeling in STZ/HFD-Treated ApoE−/− Mice2026