Key result
Following myocardial infarction in adult mice, de novo vessel formation occurs via reactivation of developmental mechanisms, including endocardial compaction and epicardial expansion, which are dependent on thymosin β4.
Population
Adult mice subjected to permanent ligation of the left anterior descending coronary artery to induce…
Comparison
Myocardial infarction and genetic lineage tracing. vs Sham-operated mice.
Design
Preclinical
Follow-up
Up to 14 days
Authors
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May support thymosin β4 as a post-MI revascularization target; hypothesis-generating in mice and leaves open human translation.
The adult mouse heart reactivates developmental mechanisms, including endocardial compaction and coronary sinus sprouting, to revascularize ischemic tissue after myocardial infarction, highlighting potential therapeutic targets.
Dubé et al. (2017) studied Myocardial infarction. Thymosin β4 knockout and genetic lineage tracing after myocardial infarction vs. Wild-type or sham-operated mice was evaluated on Endogenous neovascularization and epicardial/endocardial remodeling. Following myocardial infarction in adult mice, de novo vessel formation occurs via reactivation of developmental mechanisms, including endocardial compaction and epicardial expansion, which are dependent on thymosin β4.
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