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Naproxen, a non-steroidal anti-inflammatory drug (NSAID), was complexed with zinc (II) metal. Tests were performed to determine the analgesic, anti-inflammatory and ulcerogenic effects of zinc-naproxen compared with naproxen. Compared with naproxen, on a molar equivalent basis, the zinc-naproxen complex was found to have greater analgesic activity (acetic acid-induced abdominal constriction and tail-flick tests in mice) and comparable anti-inflammatory activity (rat paw oedema). The zinc-naproxen complex was also less ulcerogenic than naproxen in a chronic gastric injury model. Complexation of naproxen with zinc markedly reduces its ulcerogenic effect with better analgesic and comparable anti-inflammatory effects.
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Jain et al. (1999) studied this question.
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