Key result
In the Chinese population, the ACE gene DD genotype was associated with an increased risk of diabetic retinopathy compared to the II genotype (OR 1.73; 95% CI 1.19-2.51).
Why the study?
Is the ACE gene I/D polymorphism associated with diabetic retinopathy in the Chinese population?
Meta-Analysis (n=2,224)
Is the ACE gene I/D polymorphism associated with diabetic retinopathy in the Chinese population?
The ACE gene I/D polymorphism D allele is associated with an increased risk of proliferative diabetic retinopathy in the Chinese population.
Answers are grounded in this paper and cite their sources.
Does not support ACE genotyping in Chinese diabetics; extends observational evidence but remains hypothesis-generating.
OBJECTIVE: The angiotensin-converting enzyme (ACE) gene has been implicated in the development of diabetic retinopathy (DR). However, the results have been conflicting. In this study, we performed a meta-analysis to assess the association of insertion/deletion (I/D) polymorphism in the ACE gene with DR in the Chinese population. METHODS: Published literature from PubMed, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. RESULTS: Seventeen studies (1039 cases and 1185 controls) for I/D polymorphism in the ACE gene were identified. The results suggested that I/D polymorphism D allele might increase the risk of DR (DD vs. II: OR = 1.73, 95% CI 1.19-2.51; DD+ID vs. II: OR = 1.41, 95% CI 1.16-1.72; DD vs. ID+II: OR = 1.55, 95% CI 1.13-2.12). Subgroup analyses based on the type of DR showed that the effect size was statistically significant for proliferative DR (PDR) (DD vs. II: OR = 2.67, 95% CI 1.53-4.64; DD+ID vs. II: OR = 1.86, 95% CI 1.18-2.93; DD vs. ID+II: OR = 2.22, 95% CI 1.38-3.55), but not for background DR (BDR) (DD vs. II: OR = 1.38, 95% CI 0.85-2.25; DD+ID vs. II: OR = 1.40, 95% CI 0.98-2.02; DD vs. ID+II: OR = 1.15, 95% CI 0.74-1.79). CONCLUSION: The results indicated that I/D polymorphism in the ACE gene was associated with PDR, but not with BDR in the Chinese population.
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Lu et al. (2012) conducted a meta-analysis in Diabetic retinopathy (n=2,224). ACE gene I/D polymorphism (DD genotype) vs. II genotype was evaluated on Risk of diabetic retinopathy (OR 1.73, 95% CI 1.19-2.51). In the Chinese population, the ACE gene DD genotype was associated with an increased risk of diabetic retinopathy compared to the II genotype (OR 1.73; 95% CI 1.19-2.51).
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