Key result
A past history of bleeding (OR 12.38) and other factors including female gender, cancer, smoking, heart failure, and renal insufficiency independently predicted gastrointestinal bleeding in PCI patients on DAPT.
Why the study?
DAPT after PCI is strongly associated with an increased risk of gastrointestinal bleeding, which affects patient recovery and increases healthcare burden.
What are the independent risk factors for gastrointestinal bleeding in patients undergoing PCI treated with DAPT?
Observational (n=380)
No
What are the independent risk factors for gastrointestinal bleeding in patients undergoing PCI treated with DAPT?
Female gender, prior bleeding, cancer history, smoking, heart failure, and renal insufficiency independently predict gastrointestinal bleeding in patients on DAPT after PCI.
Female gender, bleeding/cancer history, smoking, HF, and renal insufficiency associated with post-PCI GIB on DAPT; supports risk models but needs prospective validation.
Following percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is key to preventing thrombosis. However, the use of DAPT is strongly associated with an increased risk of Gastrointestinal Bleeding, which not only affects patient recovery but also increases the healthcare burden. This study aims to determine the influence of past medical history and factors during hospitalization on the development of postoperative GIB in patients undergoing PCI with DAPT. A total of 380 patients were collected in this study. A total of 42 patients developed GIB during the 1-year follow-up period. Preoperative and postoperative clinical data and past medical history of patients were collected to study the correlates affecting the occurrence of GIB in the postoperative period in patients undergoing PCI with DAPT and to establish a prediction model. Single-factor logistic regression analysis showed: gender, age, past history of bleeding, past history of cancer or tumor, smoking history, history of heart failure, history of PPI use, renal insufficiency, and hypoproteinemia are potential risk factors that may influence the occurrence of GIB postoperatively in patients undergoing DAPT for PCI, P < .2. The data obtained were further included in multi-factor logistic regression analysis: gender (female), past history of bleeding, past history of cancer or tumor, smoking history, heart failure, renal insufficiency were independent risk factors influencing the occurrence of GIB postoperatively in PCI patients undergoing DAPT, P < .05. The findings of this study confirm that gender (female), past history of bleeding, past history of cancer or tumor, smoking history, heart failure and renal insufficiency are independent risk factors for the development of GIB postoperatively in PCI patients undergoing DAPT.
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Fan et al. (2025) conducted an observational in Coronary artery disease requiring percutaneous coronary intervention (PCI) and dual antiplatelet therapy (DAPT) (n=380). Past history of bleeding vs. No past history of bleeding was evaluated on Gastrointestinal bleeding (OR 12.38, 95% CI 5.24-29.24, p=<0.001). A past history of bleeding (OR 12.38) and other factors including female gender, cancer, smoking, heart failure, and renal insufficiency independently predicted gastrointestinal bleeding in PCI patients on DAPT.
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