Key result
Circulating microRNAs, such as miR-223, miR-126, and miR-19b-1-5p, show potential as diagnostic and prognostic biomarkers for assessing platelet reactivity and therapeutic response to antiplatelet drugs.
Why the study?
Circulating miRNAs may serve as diagnostic and prognostic biomarkers of platelet reactivity during antiplatelet therapy and novel therapeutic targets in cardiovascular diseases.
Circulating miRNAs may serve as novel biomarkers to monitor platelet reactivity and tailor antiplatelet therapy in patients with cardiovascular diseases.
miRNAs may refine antiplatelet response monitoring in CVD; leaves open clinical adoption pending prospective trials.
MicroRNAs (miRNAs) are small, non-coding RNAs, able to regulate cellular functions by specific gene modifications. Platelets are the major source for circulating miRNAs, with significant regulatory potential on cardiovascular pathophysiology. MiRNAs have been shown to modify the expression of platelet proteins influencing platelet reactivity. Circulating miRNAs can be determined from plasma, serum, or whole blood, and they can be used as diagnostic and prognostic biomarkers of platelet reactivity during antiplatelet therapy as well as novel therapeutic targets in cardiovascular diseases (CVDs). Herein, we review diagnostic and prognostic value of miRNAs levels related to platelet reactivity based on human studies, presenting its interindividual variability as well as the substantial role of genetics. Furthermore, we discuss antiplatelet treatment in the context of miRNAs alterations related to pathways associated with drug response.
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Czajka et al. (2021) conducted a review in Cardiovascular diseases requiring antiplatelet therapy. Antiplatelet therapy (ASA, P2Y12 inhibitors) was evaluated. Circulating microRNAs, such as miR-223, miR-126, and miR-19b-1-5p, show potential as diagnostic and prognostic biomarkers for assessing platelet reactivity and therapeutic response to antiplatelet drugs.
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