Why the study?
Does ticlopidine prevent stroke more effectively than aspirin in patients with warning TIAs?
Population
Patients in the Ticlopidine Aspirin Stroke Study with warning TIAs or stroke, including a subgroup of 1,188…
Comparison
Ticlopidine vs Aspirin
Design
Cohort
Authors
Discussion
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Implication
Ticlopidine may offer subgroup-specific benefit over aspirin post-TIA; hypothesis-generating and should not yet change practice without RCTs.
Structured PICO
Does ticlopidine prevent stroke more effectively than aspirin in patients with warning TIAs?
P
Population
Patients in the Ticlopidine Aspirin Stroke Study (TASS) with warning TIAs or stroke, including a subgroup of 1,188 patients with carotid qualifying events who underwent arteriography.
I
Intervention
Ticlopidine
C
Comparator
Aspirin
O
Outcome
Prevention of strokehard clinical
Ticlopidine appears more effective than aspirin for secondary stroke prevention in specific subgroups, including women, patients with vertebrobasilar symptoms, and those with diffuse atherosclerotic disease.
Cite This Study
Grotta et al. (1992) studied this question.