A Study Comparative of Some Haematological Parameters after Treatment by Extracted Octacosanol and Atorvastatin in Female Rats

Hematological and serum parameters are a prerequisite to understand the normal functioning of the system and to confirm the nontoxic nature of the administered crude drug. Hematological parameters such as mean platelet volume (MPV) and RBCs count are associated with the increased risk for cardio vascular diseases CVD. Octacosanol is the major effective component of policosanol forming about (62.9%), it has antioxidative, lipid lowering, antithrombotic (antiplatelet) effects and provides protection against free radical associated diseases. Statins are the inhibitors of hydroxymethyl glutaryl coenzyme A (HMG CoA) reductase. They are mostly used to treat hyperlipidaemia. Statins such as atorvastatin and some of medical plants have shown their beneficial effect on the cardiovascular disease (CVD) by virtue of their lipid lowering, antioxidant and cardioprotective effects. The present study was designed to compare some of hematological parameters after treatment of extracted octacosanol and atorvastatin in female Norwegian rats. Thirty two females rat with (10-12) weeks old-and weighting (200-250 gm) were used in the current study. Policosanol was extracted from sugarcane that obtained from Mesan province. Octacosanol is determined in this extraction by gas chromatography mass spectrometry (GC/MS). Animals were divided into 4 equal