What question did this study set out to answer?

To determine whether frequent reinfection by endemic seasonal coronaviruses is driven by viral antigenic drift rather than solely by waning host immunity.

January 18, 2021eLifeOpen Access

Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e

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To determine whether frequent reinfection by endemic seasonal coronaviruses is driven by viral antigenic drift rather than solely by waning host immunity.
Evaluated genetic variation and evolutionary selection pressure across the spike proteins of seasonal coronaviruses OC43, 229E, NL63, and HKU1.
Analyzed genomic regions targeted by human humoral immunity, focusing on antibody-exposed sites in the receptor-binding domain.
Identified clear evidence of adaptive evolution within the surface-exposed spike protein regions of coronaviruses OC43 and 229E.
Demonstrated that positive selection in antigenic regions enables these viruses to evade recognition by host humoral immunity.
Observed evolutionary dynamics comparable to seasonal influenza, suggesting vaccine formulations against these viruses may require periodic updates.

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Implication

Genomic analysis reveals adaptive evolution in seasonal coronaviruses OC43 and 229E, indicating that antigenic drift drives recurrent human reinfections.

Cite This Study

Kistler et al. (2021) studied this question.

synapsesocial.com/papers/6a9436cebeaf7a0a159c60d5 https://doi.org/10.7554/elife.64509

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Implication

Genomic analysis reveals adaptive evolution in seasonal coronaviruses OC43 and 229E, indicating that antigenic drift drives recurrent human reinfections.

Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e

Key Points

Discussion

Implication

Cite This Study

Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e

Key Points

Discussion

Implication

Cite This Study

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