Abstract —l‐Glutamine is taken up into rat brain slices by a specific‘high affinity’uptake system (Km 52 μm) which is not influenced by high concentrations of l‐glutamate and l‐asparagine. The uptake system appears to be associated with cellular structures that do not survive homogenization under conditions which yield synaptosomes. The‘high affinity’uptake of glutamine is dependent on the external sodium ion concentration and can be inhibited by p‐chloromercuriphenylsulphonate, amino‐oxyacetic acid, ouabain, dibenamine and allylglycine. The effects of several inhibitors indicate that l‐asparagine uptake is mediated by a system different from the‘high affinity’system mediating l‐glutamine uptake.
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Balcar et al. (1975) studied this question.
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