Key result
Airway-associated adipose tissue was identified as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines that may adversely affect lung function.
Airway-associated adipose tissue is identified as a prominent airway wall structure that may act as a local source of pro-inflammatory adipokines affecting lung function.
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May link peribronchial fat to lung impairment; leaves open therapeutic targeting in obesity-related airway disease.
Extract Obesity is a leading risk factor for severe asthma, where patients experience recurrent exacerbations and frequent hospitalisations [1]. Reduced lung function in these individuals is potentially driven by extra-thoracic and abdominal adiposity compressing the chest cavity, or through adipokines circulated from visceral and subcutaneous adipose tissues that exacerbate airway inflammation [2]. We identified airway-associated adipose tissue as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines [3, 4] that may adversely affect lung function.
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Wang et al. (2025) studied Asthma and obesity. Overweight/obesity vs. Healthy weight was evaluated on Structural composition of airway wall fat. Airway-associated adipose tissue was identified as a prominent airway wall structure, representing a local source of pro-inflammatory adipokines that may adversely affect lung function.
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