June 1, 1997Neurology
EEG spectral abnormalities and psychosis as predictors of cognitive and functional decline in probable Alzheimer's disease
Key result
The presence of an abnormal EEG or psychotic symptoms at baseline independently predicted a higher risk of severe cognitive and functional impairment in patients with probable Alzheimer's disease.
Why the study?
Do EEG abnormalities or psychosis predict cognitive and functional decline in patients with probable Alzheimer's disease?
Population
95 probable Alzheimer's disease patients participating in a longitudinal study of dementia
Comparison
Presence of abnormal EEG or psychotic symptoms… vs Normal EEG or absence of psychotic symptoms
Design
Cohort
Authors
Discussion
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Implication
May guide prognostic counseling in probable Alzheimer's disease; leaves open need for interventional studies.
Study Design
Type
Cohort (n=95)
Structured PICO
Do EEG abnormalities or psychosis predict cognitive and functional decline in patients with probable Alzheimer's disease?
P
Population
95 patients with probable Alzheimer's disease participating in a longitudinal study of dementia.
E
Exposure
Presence of abnormal EEG (based on parasagittal mean frequency) or psychotic symptoms at baseline
C
Comparator
Normal EEG or absence of psychotic symptoms
O
Outcome
Reaching severe cognitive and functional impairment during follow-up
Both abnormal EEG and psychosis are independent predictors of cognitive and functional disease progression in Alzheimer's disease, but not of physical survival.
Cite This Study
López et al. (1997) conducted a cohort in probable Alzheimer's disease (n=95). Abnormal EEG and psychotic symptoms vs. Normal EEG and absence of psychotic symptoms was evaluated on Severe cognitive and functional impairment. The presence of an abnormal EEG or psychotic symptoms at baseline independently predicted a higher risk of severe cognitive and functional impairment in patients with probable Alzheimer's disease.