The Effects of Pericapsular nerve group (PENG) block on Postoperative Recovery in Elderly Patients with Hip fracture: a study protocol for randomized, parallel controlled, double-blind trial

Introduction Hip fracture is a common and serious emergency in the elderly, it is associated with severe pain, significant postoperative morbidity and mortality. Featuring peripheral nerve block in Enhanced recovery after surgery (ERAS) pathway may have significantly effect on shortening length of hospital stay, decreasing complications and costs, particular in improvement in dynamic pain and reducing the use of opioid. Pericapsular Nerve Group Block(PENG), suggested by Arango et al , may provide a effective blockade to the articular branches of the anterior hip joint,which innervate the most section of the hip capsule richly, with a potential motor-sparing effect.The purpose of this trail is to investigate whether PENG is effective to enhanced recovery in elderly patients with hip fracture. Methods and analysis This study will be a single centre,randomized, parallel controlled, double-blind trail. 92 elderly patients scheduled for hip fracture surgery will be divided into two groups randomly to receive ultrasound-guided PENG block or ultrasound-guided femoral nerve(FN) block. The primary outcome will be compare the quality of recovery-15(QoR-15) score at 24h postoperatively between two groups.The secondary outcomes include the strength of quadriceps, the visual analogue scale(VAS) at rest and on movement, the total morphine consumption, the rescue analgesic, the first time of postoperative out-of-bed mobilization, the complications. Ethics and dissemination This study has been approved by the Medical Science Research Ethics Committees of The First Affiliated Hospital of Guangzhou University of Chinese Medicine on 15 December 2020 (Reference K2020-110). The results of this study will be published in peer-reviewed international journals. Trial registration number ChiCTR2100042341.