Peste Des Petits Ruminants Virus Nucleocapsid Protein Interacts with Protein Kinase R-Activating Protein and Induces Stress Granules To Promote Viral Replication

Shuying Chen; Fan Yang; Weijun Cao; Xiangle Zhang; Huisheng Liu; Keshan Zhang; Xiangtao Liu; Jingyu Wang; Haixue Zheng; Zixiang Zhu

doi:10.1128/jvi.01712-22

January 18, 2023Journal of VirologyOpen Access

Peste Des Petits Ruminants Virus Nucleocapsid Protein Interacts with Protein Kinase R-Activating Protein and Induces Stress Granules To Promote Viral Replication

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Abstract

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cells. SGs induced by PPRV infection through the PKR/eIF2α pathway are PACT dependent. The loss-of-function assay indicated that PPRV-induced SGs were critical for PPRV replication. We concluded that the PPRV N protein manipulates the host PKR/eIF2α/SG axis to favor virus replication.

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Chen et al. (2023) studied this question.

synapsesocial.com/papers/6a943b013c3b3bc8ec6d2fac https://doi.org/10.1128/jvi.01712-22

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Peste Des Petits Ruminants Virus Nucleocapsid Protein Interacts with Protein Kinase R-Activating Protein and Induces Stress Granules To Promote Viral Replication

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Peste Des Petits Ruminants Virus Nucleocapsid Protein Interacts with Protein Kinase R-Activating Protein and Induces Stress Granules To Promote Viral Replication

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