The histone proteins that constitute the nucleosomes of chromatin around which yards of DNA are wrapped undergo a series of chemical modifications during gene activation and gene silencing. In a Perspective, Berger discusses new results ( Nakayama et al .) that elucidate the sequence of reactions that modify histone H3 and how these modifications translate into gene silencing in fission yeast.
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Shelley L. Berger (2001) studied this question.
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