Key result
Bushen Qinggan Formula added to amlodipine significantly improved blood pressure variability and endothelial function compared to placebo (P<0.01), but showed no significant antihypertensive effects.
Why the study?
Does Bushen Qinggan Formula improve blood pressure variability and endothelial function in patients with essential hypertension treated with amlodipine?
Population
150 patients with essential hypertension
Comparison
Bushen Qinggan decoction or Bushen Qinggan… vs Placebo added to standard medication for 8 weeks
Design
RCT, randomly assigned
Follow-up
8 weeks
Authors
Loading...
May support adjunctive use for BP variability and endothelial function; extends RCT evidence for traditional formulas beyond mean BP reduction.
RCT (n=150)
randomly assigned
Does Bushen Qinggan Formula improve blood pressure variability and endothelial function in patients with essential hypertension treated with amlodipine?
p-value: p=<0.01
Bushen Qinggan Formula added to amlodipine improves blood pressure variability and endothelial function in hypertensive patients, though it does not further lower mean blood pressure.
Wu et al. (2014) conducted an RCT in essential hypertension (n=150). Bushen Qinggan Formula (decoction or granule) vs. Placebo was evaluated on Reduction in mean blood pressure (MBP), blood pressure variability (BPV), and changes in endothelial markers (ET-1 and NO) (p=<0.01). Bushen Qinggan Formula added to amlodipine significantly improved blood pressure variability and endothelial function compared to placebo (P<0.01), but showed no significant antihypertensive effects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: