Key result
Abrupt cessation of paroxetine in three patients resulted in withdrawal symptoms suggestive of a serotonergic effect.
Why the study?
Does abrupt cessation of paroxetine cause withdrawal symptoms in patients with depression?
Case Report (n=3)
Does abrupt cessation of paroxetine cause withdrawal symptoms in patients with depression?
Abrupt cessation of paroxetine can lead to withdrawal symptoms, likely related to its potency for serotonin re-uptake inhibition and pharmacokinetics.
Answers are grounded in this paper and cite their sources.
Supports gradual paroxetine tapering; leaves open confirmation in controlled trials.
Cessation of tricyclic antidepressant drugs can result in ‘cholinergic type’ withdrawal symptoms. There is also evidence for withdrawal symptoms following sudden cessation of SSRI antidepressants. Observations made on three patients are described following abrupt cessation of paroxetine, prescribed for treatment of depression. The withdrawal symptoms described are suggestive of some form of serotonergic effect and the different frequencies with different SSRIs may relate to their different potencies for serotonin re-uptake inhibition as well as to pharmacokinetic differences.
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Milliken et al. (1998) conducted a case report in Depression (n=3). Abrupt cessation of paroxetine was evaluated on Withdrawal symptoms. Abrupt cessation of paroxetine in three patients resulted in withdrawal symptoms suggestive of a serotonergic effect.
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