July 18, 2006Cochrane library
Treatment discontinuation with selective serotonin reuptake inhibitors (SSRIs) versus tricyclic antidepressants (TCAs)
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Discussion
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Implication
Randomized trial compares tolerability of SSRIs and TCAs in treating depression, suggesting modest advantages for SSRIs.
Key Points
- To assess the comparative tolerability of SSRIs and tricyclic/heterocyclic antidepressants with a focus on drop-out rates.
- Parallel group randomized controlled trials were included, comparing SSRIs and TCAs in individuals with depression.
- A total of 136 trials were evaluated by independent reviewers for drop-out rates and tolerability.
- Data extraction discrepancies were resolved by a third reviewer.
- SSRIs showed lower drop-out rates compared to TCAs with an odds ratio of 1.21 (95% CI 1.12 to 1.30).
- A statistically significant difference in drop-outs was observed between SSRIs and both old and new tricyclics.
- No significant difference was noted in the comparison of SSRIs to heterocyclic antidepressants.
Cite This Study
Barbui et al. (2006) studied this question.