Why the study?
Do SSRIs improve tolerability and reduce withdrawal rates compared to TCAs in older depressed patients?
Population
11 RCTs pooling 1,091 older depressed patients (537 TCA recipients and 554 SSRI recipients)
Comparison
Selective serotonin reuptake inhibitors (SSRIs) vs Tricyclic antidepressants including classical…
Design
Meta-analysis
Authors
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SSRIs preferred over TCAs for tolerability in older depression; confirms first-line SSRI recommendations in guidelines.
Do SSRIs improve tolerability and reduce withdrawal rates compared to TCAs in older depressed patients?
SSRIs are generally better tolerated than classical TCAs in older depressed patients, though TCA-related drugs like mianserin and trazodone have comparable tolerability.
Wilson et al. (2004) studied this question.
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