Why the study?
Do TCAs and SSRIs improve depression compared with placebo in primary care patients?
Population
Patients with depression in a primary care setting from 15 randomized controlled trials
Comparison
Tricyclic antidepressants or selective serotonin… vs Placebo
Design
Meta-analysis
Follow-up
typically 6 to 8 weeks
Authors
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Both TCAs and SSRIs improve depression in primary care; confirms efficacy versus placebo and supports guideline-directed use.
Do TCAs and SSRIs improve depression compared with placebo in primary care patients?
Both TCAs (including low-dose) and SSRIs are effective for treating depression in primary care compared with placebo.
Bruce Arroll (2005) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: