Why the study?
Do SSRIs have a better safety and tolerability profile compared to TCAs in depressed patients?
Population
Depressed patients
Comparison
Selective serotonin reuptake inhibitors (SSRIs) vs Tricyclic antidepressants (TCAs)
Design
Review
Authors
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May support SSRIs over TCAs for safety in depression; leaves open need for updated RCTs in modern cohorts.
Do SSRIs have a better safety and tolerability profile compared to TCAs in depressed patients?
SSRIs offer a significantly more favorable safety and tolerability profile than TCAs for the treatment of major depression, including lower toxicity in overdose.
Peretti et al. (2000) studied this question.
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